Pasteurella multocida Heddleston serovar 3 and 4 strains share a common lipopolysaccharide 1 biosynthesis locus but display both inter - and intra - strain lipopolysaccharide heterogeneity
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چکیده
Pasteurella multocida Heddleston serovar 3 and 4 strains share a common lipopolysaccharide 1 biosynthesis locus but display both interand intra-strain lipopolysaccharide heterogeneity. 2 3 Marina Harper, Frank St. Michael, Marietta John, Evgeny Vinogradov, Jennifer A. Steen, 4 Lieke van Dorsten, Jason A. Steen, Conny Turni, Patrick J Blackall, Ben Adler, Andrew 5 D. Cox and John D. Boyce 6 7 Australian Research Council Centre of Excellence in Structural and Functional Microbial 8 Genomics, Department of Microbiology, Monash University, Melbourne, Australia, 3800. 9 2 Institute for Biological Sciences, National Research Council, Ottawa, ON, Canada, K1A 0R6. 10 3 Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Dutton 11 Park, Brisbane, Australia 4102. 4 Department of Microbiology, Monash University, Melbourne, 12 Australia, 3800 13 † Joint senior author 14 15 Running title: Analyses of P. multocida serovar 3 and 4 LPS 16
منابع مشابه
Pasteurella multocida Heddleston serovar 3 and 4 strains share a common lipopolysaccharide biosynthesis locus but display both inter- and intrastrain lipopolysaccharide heterogeneity.
Pasteurella multocida is a Gram-negative multispecies pathogen and the causative agent of fowl cholera, a serious disease of poultry which can present in both acute and chronic forms. The major outer membrane component lipopolysaccharide (LPS) is both an important virulence factor and a major immunogen. Our previous studies determined the LPS structures expressed by different P. multocida strai...
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Pasteurella multocida strains are classified into 16 Heddleston serovars on the basis of the lipopolysaccharide (LPS) antigens expressed on the surface of the bacteria. The LPS structure and the corresponding LPS outer core biosynthesis loci of strains belonging to serovars 1, 2, 3, 5, 9 and 14 have been characterized, revealing a clear structural basis for serovar classification. However, seve...
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Pasteurella multocida strains are classified into 16 different lipopolysaccharide (LPS) serovars using the Heddleston serotyping scheme. Ongoing studies in our laboratories on the LPS aim to determine the core oligosaccharide (OS) structures expressed by each of the Heddleston type strains and identify the genes and transferases required for the biosynthesis of the serovar-specific OSs. In this...
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Pasteurella multocida is a Gram-negative bacterial pathogen that is the causative agent of a wide range of diseases in many animal species, including humans. A widely used method for differentiation of P. multocida strains involves the Heddleston serotyping scheme. This scheme was developed in the early 1970s and classifies P. multocida strains into 16 somatic or lipopolysaccharide (LPS) serova...
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Pasteurella multocida is a Gram-negative bacterial pathogen classified into 16 serovars based on lipopolysaccharide (LPS) antigens. Previously, we have characterized the LPS outer core biosynthesis loci L1, L2, L3, L5 and L7, and have elucidated the full range of LPS structures associated with each. In this study, we have determined the LPS structures produced by the type strains representing t...
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